Univariable and multivariable analysis for time to first treatment. (A) Forest plot of the hazard ratio for the 19 covariates assessed for association with TTFT by univariable analysis. Solid boxes indicate the hazard ratio, horizontal lines indicate the 95% CIs. The red dot line marks hazard ratio of 1. The bar graph on the left shows the multiplicity adjusted -log10 P value by Bonferroni. The red solid line marks the .05 significance level. (B) Forest plot of the hazard ratio for the 5 covariates assessed for association with TTFT by multivariable analysis. Solid boxes indicate the hazard ratio, horizontal lines indicate the 95% CIs. The red dot line marks hazard ratio of 1. The bar graph on the left shows the -log10 P value. The red solid line marks the .05 significance level. (C-D) The bar plot shows the percentage of covariate selection in the final multivariable model across the 9 Binet A validation cohorts. The red line indicates the threshold selected as inclusion criteria in the final model.