Meta-analysis of the estimate of the IPS-E discrimination capacity of TTFT across the study cohorts. Forest plot of the C-index of the 10 Binet A cohorts according to the IPS-E. Solid boxes indicate C-index in each study with dimensions proportional to sample size weights, horizontal lines indicate bootstrap 95% CIs. The red rhombus represents the overall estimate by the meta-analysis. MDACC, M.D. Anderson Cancer Center; SU, Sapienza University.