Meta-analysis of the estimates of the IPS-E cumulative incidence of treatment need across the study cohorts. Forest plots of the (A) 1- and 5-year cumulative incidence of treatment need across the 10 Binet A cohorts according to the IPS-E. (B) Forest plots of the number of treatment events per 100 person-years across the 10 Binet A cohorts according to the IPS-E. Solid boxes indicate the estimate in each study with dimensions proportional to sample size weights; horizontal lines indicate 95% CIs. The red rhombus represents the overall estimate by the meta-analysis.