Baseline gene expression of JAK-STAT and BCL2 family members and correlation to ruxolitinib IC₅₀. Selected gene expression was measured in CTCL patient samples (n = 11) and normal control samples (n = 5). Results are expressed as a fold change from the mean of normal control samples. (A) Significantly increased JAK2, STAT5B, and BCL2L2 expression and decreased BCL2 expression were noted in CTCL patient samples relative to control samples. (B) JAK2 expression (fold change in malignant patient-derived cells compared with normal lymphocytes) may predict response to ruxolitinib in vitro, with higher JAK2 expression moderately correlated to sensitivity. *P < .05; ***P < .0001.