Kaplan-Meier OS estimates for 483 patients with corresponding numbers at risk. Stratification is by LR, IR, and HR groups incorporating base model predictors of R-ISS and age ≥70 years (A), base model and metaphase cytogenetics (B), base model and metaphase del(13q)/monosomy 13 (C), base model and hypodiploid karyotype (D), base model and nonhyperdiploid karyotype (E), base model and metaphase gain 1q (F), and base model and PCPro (G). Corresponding P values for log-rank tests are provided.