CH mutations detected in the MRD⁻samples of 149 patients. (A) Flowchart of study patients. (B) Landscape of CH mutations in 149 MRD⁻ post-ASCT samples. (C) Prevalence of CH mutations in MRD⁻ samples from postinduction (n = 59) and post-ASCT (n = 149) time points. Statistics by χ² test. (D) Variant allele frequency (VAF) of 9 postinduction CH mutations and 54 post-ASCT CH mutations. Analyzed by Mann-Whitney U test. (E) Overall survival of patients with and without CH mutations at post-ASCT time point, compared by log-rank test.