Molecular alterations in ECD. (A) Graphic depicting MAPK pathway signaling in ECD with therapeutic targets. The lightning bolts indicate the most common genes that are altered in ECD. (B) Composite of all somatic alterations (mutations and fusions) that have been reported in ECD to date. *Mutations identified in plasma cell-free DNA analysis only; therefore, these could reflect somatic mutations from another diagnostic entity (eg, clonal hematopoiesis).