Histophenotypical features of BI-associated DLBCLs. In case 1, the capsule was infiltrated by cell aggregates within fibrin deposits (A, hematoxylin & eosin [H&E] stain ×25), and neoplastic cells disclosed pleomorphic irregular nuclei, with slightly lytic features and apoptotic bodies (B, H&E stain ×400); they expressed CD20 (C, immunohistochemistry [IHC] stain ×200), CD30 (D, IHC stain ×400), and LMP1 (E). In case 2, the breast tumor was composed of dense cell aggregates within abundant fibrinous deposits (F, H&E stain ×25) but also showed massive capsule invasion (G, H&E stain ×25). Hyperplasic lymphoid follicles were present in the external part of the capsule (G, *). Tumor cells displayed plasmablastic features (H, H&E stain ×600). CD79a was positive in a minority of lymphoma cells (I, IHC stain ×400), whereas CD30 was positive (J, IHC stain ×400) and the Ki-67 proliferative index was ~100% (K, IHC stain ×200). P-STAT3 was also positive (L, IHC stain ×600). In situ hybridization showed that virtually all neoplastic cells were EBV infected (M, EBER stain ×25). In case 3, cell aggregates were mostly located at the surface of the capsule within fibrinous deposits (N, H&E stain ×25). Hyperplasic lymphoid follicles were present in the deep capsule (N, *). Atypical large cells were altered by early necrosis (O, H&E stain ×400); they displayed CD20 (P, IHC stain ×400) and EBNA2 positivity (Q, IHC stain ×400).