Mutational profile of tumors. (A) Resequenced somatic mutations observed in tumor exome sequencing dataset of 6 patients, A1 to 2, and L1 to 4 classified by type. (B) Frequency and type of probable driver mutations and recurrent mutations. Nonsilent mutations (missense-, nonsense-, and splicing-mutations, and frameshift/in frame insertions/deletions), which occurred in genes that are significantly mutated in ATL,¹⁴  were considered putative driver mutations (CCR4 to ZFP36L2). Patient A2 had an additional silent mutation in NOXA1; patient L2 also had silent mutations in TP53 and PIK3CD, and an intronic mutation in POT1. Genes that were recurrently mutated within the cohort were also plotted (MUC16 to ZFPM2).