Meta-analysis of the prognostic impact of assigned BAGS subtypes. Progression-free survival (PFS) (A) and OS (B) were compared between BAGS subtypes for high-dose melphalan–treated patients in published prospective clinical trials. P values are results from log-rank tests. The subtype numbers given as n are the numbers of events/number of assigned patients with the subtypes in the meta–data set. The BAGS subtypes are color coded as in Figure 1.