Bubble plots of prevenetoclax and postvenetoclax CCFs of mutations in BTK, PLCG2, and BCL2. Bubble size represents cancer cell fraction (CCF; 0% to 100%), and relapse bubble color encodes absolute gain or loss of clone size. Three patients with Richter-type progression are highlighted in red. CCF was adjusted for patient X-chromosome ploidy. Abs. Δ CCF, absolute change in cancer cell fraction.