PFS and OS. Kaplan-Meier plots of PFS and OS. (A) For all patients, median PFS was 1.7 mo and median OS was 2.7 mo. (B) PFS for OR patients (5.1 mo) differed significantly from nonresponders (PD/SD) (1.3 mo; P = .008; HR, 3.1). (C) OS for OR patients (9.7 mo) differed significantly from nonresponders (PD/SD) (2.7 mo; P = .01; HR, 3.1). Statistical significance was determined using the Mantel-Byar method. Black marks indicate censored data at the last date a patient was known to be alive.