The patient’s signs and family pedigree. (A) The patient’s family pedigree. The patient is a fraternal triplet and his parents were second cousins. He is homozygous for G1289A mutation of the TM gene. Other family members are heterozygous for this mutation. (B) Subcutaneous bleeding that repeatedly appeared almost every week. (C) Brain computed tomography scan showing an old cerebral infarction, possibly due to embolism with a blood clot that was formed in the venous system and shifted to an arterial current through the foramen ovale during the fetal period.