Tumor response and CAR-T cell expansion after infusion. (A) Tumor volume change (relative to tumor volume at day 0) for patients 2, 4, and 5. (B) Tumor volume change (relative to tumor volume at day 0) for patient 1 treated with CD19 and CD22 directed CAR-T cell therapy. (C) Tumor volume change (relative to tumor volume at day 0) for patient 3 treated with CD19, CD22, and CD20 directed CAR-T cell therapy. (D) CAR-T cells absolute number change for patients 2, 4, and 5. (E) CAR-T cells absolute number change for patient 1 treated with CD19 and CD22 directed CAR-T cell therapy. (F) CAR-T cells absolute number change for patient 3 treated with CD19, CD22, and CD20 directed CAR-T cell therapy. Single major tumor volume was measured by computed tomography or B-ultrasound.