Platelet responses to collagen and CRP-XL in patients stratified by clinical outcome and presence of coagulopathy. (A) Area coverage after adhesion to type 1 collagen under flow conditions in survivors (n = 10) and nonsurvivors (n = 4). (B-C) Aggregation in response to type 1 (Horm) collagen (B) and CRP-XL (C) in survivors (n = 13) and nonsurvivors (n = 7). (D-E) Correlation between adhesion to collagen under flow and CA5 on ROTEM in the presence of tissue factor (EXTEM; D) and after subtraction of cytochalasin D assay to isolate platelet contribution to CA5 (EXTEM-FIBTEM; E). (F-G) Aggregation in response to collagen (F) and CRP-XL (G) in patients with (n = 13) and without (n = 7) TIC. Student t test (A) or 2-way ANOVA with Šidák’s multiple-comparisons test (B-C,F-G). *P < .05; **P < .01; ***P < .001.