Figure 2.
Heat map of SNP scores for H3K27Ac and H3K4me3 at each Hodgkin lymphoma risk locus. SNP score calculated as per Trynka et al.29 For each SNP at a given locus, the score represents the height of the closest ChIP-seq peak divided by the distance to the summit in each cell line, normalized across all immune cell types. Thus, a SNP within a chromatin mark that is active in only 1 cell type will have a high score of 1 (red) in that cell type and 0 (white) in others. In contrast, a SNP close to chromatin marks that are not cell-type-specific will have similarly modest scores across cell types. Genes at each risk locus are given for identification purposes only, and do not necessarily indicate biological functionality.