Figure 2.
Figure 2. Heat map of SNP scores for H3K27Ac and H3K4me3 at each Hodgkin lymphoma risk locus. SNP score calculated as per Trynka et al.29 For each SNP at a given locus, the score represents the height of the closest ChIP-seq peak divided by the distance to the summit in each cell line, normalized across all immune cell types. Thus, a SNP within a chromatin mark that is active in only 1 cell type will have a high score of 1 (red) in that cell type and 0 (white) in others. In contrast, a SNP close to chromatin marks that are not cell-type-specific will have similarly modest scores across cell types. Genes at each risk locus are given for identification purposes only, and do not necessarily indicate biological functionality.

Heat map of SNP scores for H3K27Ac and H3K4me3 at each Hodgkin lymphoma risk locus. SNP score calculated as per Trynka et al.29  For each SNP at a given locus, the score represents the height of the closest ChIP-seq peak divided by the distance to the summit in each cell line, normalized across all immune cell types. Thus, a SNP within a chromatin mark that is active in only 1 cell type will have a high score of 1 (red) in that cell type and 0 (white) in others. In contrast, a SNP close to chromatin marks that are not cell-type-specific will have similarly modest scores across cell types. Genes at each risk locus are given for identification purposes only, and do not necessarily indicate biological functionality.

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