Nuclear FOXO1 regulates gene expression. (A) Unsupervised PCA based on global transcript expression generated from individual cell line clones (n = 3 per genotype) as analyzed in Figure 5. (B) Hierarchical clustering of transcripts (n = 1500) differentially expressed in at least 1 of the groups (FDR q value < 0.05). (C) Summary of gene ontology enrichment analysis findings based on transcripts specifically deregulated by mt FOXO1 (n = 210 upregulated; n = 103 downregulated).