Lymphomas from Uchl1^Tgmice resemble those driven by constitutive MYC and PI3KA activation. (A-C) Heat map (A), cluster dendrogram (B), and primary component analysis (PCA; C) of mRNA gene expression profiles of 5 lymphomas from Uchl1^Tg mice compared with those from the indicated genetically engineered mouse models and B-cell populations (GSE2350 and GSE26408). (D) Myc mRNA levels were determined in the 5 lymphomas from A to C and compared with purified GC B cells isolated from immunized C57BL/6 mice (n = 3). The sample with the highest Myc expression has a documented Myc rearrangement.