Role of 8 novel mouse genes in arterial thrombus formation, based on PITH network. Mice with homozygous deficiency in indicated genes were tested for arterial thrombus formation (class III). Data represent surface area coverage (SAC) of platelet thrombi on collagen. (A-B) Testing of 5 genes/proteins selected from the PITH network with suspected thrombosis phenotype. Mean plus or minus standard error (SE; n = 6-17); **P < .01. (C-D) Testing of 3 genes/proteins identified from PITH with suspected gain-of-function defect related to atherothrombosis. Mean plus or minus SE (n = 6-18); **P < .01. (B,D) Connecting edges in PITH network, and relative mRNA expression in human megakaryocytes (log2 scale). MGK, megakaryocyte.