Predictive validation of platelet counts and plasma sTLT-1 in mortality associated with ARDS. (A) Comparison of baseline platelet counts between survivors and nonsurvivors (Student t test, P = .007). Kaplan-Meier survival curves comparing survival (n = 782; log rank, P = .003) (B) and days to achieve unassisted breathing (n = 782; log rank, P = .009) (C) between patients with <80 000 plt/μL and >80 000 plt/μL. Comparison of day 1 (D) and day 3 (G) sTLT-1 levels between survivors and nonsurvivors (day 1: n = 799; Student t test, P = .012; day 3: n = 626; NS, not significant). The whiskers represent the 10th and 90th percentile. Kaplan-Meier survival curves using the day 1 sTLT-1 levels and the 1200 pg/mL cutoff to compare survival (n = 799; log rank, P < .0001) (E) and ventilation-free days (n = 799; log rank, P = .027) (F). Kaplan-Meier survival curves using the day 3 sTLT-1 levels and the 1200 pg/mL cutoff to survival (n = 684; log rank, P < .0001) (H) and ventilation free days (n = 626; log rank, P < .005) (I).