CDCN response criteria based on evaluation of biochemical, lymph node, and symptom response. Biochemical, lymph node, and response criteria have been detailed in the text. For lymph node response, Cheson criteria have been modified to include assessment of skin manifestations.42 An overall CR requires a complete biochemical, lymph node, and symptomatic response. An overall PR requires nothing less than a PR across all categories, but not meeting criteria for CR. Overall SD requires no PD in any of the categories and not meeting the criteria for CR or PR. An overall PD occurs when any category has a PD. Symptomatic and biochemical response evaluation should be done on a monthly basis until maximum response has been achieved. Radiological assessment of lymph node response by CT scanning is first recommended at 6 weeks and at 3-monthly intervals thereafter until maximum regression of lymph nodes has occurred. Lymph node response may take several months in patients treated with anti–IL-6 mAbs.