ICAM-1 mRNA and protein levels are increased by SS MPs. (A) Heat map indicating mean endothelial ICAM-1 mRNA level according to the dose of MPs, the incubation time, and the genotype of the subjects. Expression levels are normalized to the controls, without MPs. Flow cytometry analyses of a high dose of MPs and each considered genotype for each incubation time: the percentage of ICAM-1⁺ cells (B) and their MFI (C). Subjects per group: 9 ≤ n ≤ 12. The dotted lines represent the control level (without MPs) at 4 hours. ^#P < .05 vs corresponding low dose, *P < .05, **P < .01, ***P < .001, ****P < .0001 vs corresponding AA MP level.