Hypoxia upregulates TET3 expression and enhances early erythroid differentiation.TET1-3 expression in normoxia vs hypoxia at day 3 (A), day 7 (B), and day 10 (C) of in vitro erythropoiesis. DNMT1, DNMT3A, and DNMT3B expression in normoxia vs hypoxia at day 3 (D), day 7 (E), and day 10 (F) of in vitro erythropoiesis. (G-N) Expression of EPOR, GYPA, TFR2, ERFE, SLC40A1, NCOA4, SLC11A2, and SLC25A37 in normoxia vs hypoxia at day 3, 7, and 10 of in vitro erythropoiesis. N = 2 for RNA-sequencing experiments. *P < .05; **P < .01.