ETS1 ChIP analysis of human ex vivo peripheral NK cells. (A-D) ETS1 ChIP-seq analysis was performed on sorted human peripheral blood NK cells. (A) Known motifs were identified with the HOMER package, and the 4 most significant motifs are shown. (B) Locations of ETS1 ChIP peaks relative to genomic annotations. (C) Genome browser tracks of NK cell–linked transcription factor genes are shown for human NK cell ETS1 ChIP-seq vs input DNA, vs H3K4me3 and H3K27ac ChIP-seq and ATAC-sequencing. (D) Identification of the proportion of genes that are potentially directly regulated by ETS1. (E) Nonbiased analysis of enriched transcription factor motifs in the downregulated and upregulated genes of ETS1 p27 NK cells by using the computational method iRegulon.