CTCF occupancy and its distribution within the genome. (A) Experimental outline illustrating the analyses of patient samples. (B) Venn diagram displaying unique and common CTCF peaks in AML^all and NBM cells. (C) Distribution of CTCF-binding sites over genomic features. (D) Percentage of enhancers that contain a CTCF-binding site (Z-test, *P < .01). (E) Heatmap of unsupervised hierarchical clustering for the 1000 most variably bound CTCF peaks based on interquartile range measure. DMSO, dimethyl sulfoxide; UTR, untranslated region.