Loss of Morrbid enhances the survival of Shp2^E76K-driven JMML mice. (A) Generation of JMML mice (Shp2*: LysMCre; Shp2^E76K/+) and JMML mice lacking Morrbid (Shp2*M: LysMCre; Shp2^E76K/+; Morrbid^−/−) along with WT control and Morrbid^−/− (M). (B) Kaplan-Meier survival curve of Shp2* and Shp2*M mice and control animals. (C) Analysis of hematopoietic cells in PB by the automatic blood cell counter Element HT5 Analyzer. (D) Analysis of WBCs from PB by flow cytometry. Mac1⁺ staining for myeloid cells and CD19⁺ staining for B cells (n = 4-18 mice). *P < .05; **P < .01; ***P < .001; ****P < .0001. See supplemental Figure 1 for improvement of the anemia phenotype in Shp2*M mice compared with Shp2* mice. LY, lymphocytes; n.s., not significant.