14-3-3ε functional model in MM. 14-3-3ε induces the activation of mTORC1 through binding and inhibition of the TSC1/TSC2, complex as well as directly interacting and promoting phosphorylation of the mTORC1 subunit mTOR. On activation, mTORC1 phosphorylates 4E-BP1 releasing eIF4E, to allow cap-dependent mRNA translation. As a consequence, MM cell protein load increases, shifting the load/capacity balance and resulting in enhanced sensitivity to PIs.