Figure 6.
![Examples of disease cohort indexing. Multivariable representations of individual patient samples in the context of the analyzed disease cohorts. (A) Two patients with stable disease (ET [patient 1] and refractory PV [patient 2]) in whom sequential samples were available showed close clustering of the analyzed samples on the PCA plot. (B) Two patients with transformed ET (patient 3) and PV (patient 4) showed a marked shift in the multivariable representations of megakaryocytes between the chronic MPN samples and the transformed samples (post-ET myelofibrosis and post-PV myelofibrosis, respectively) on the PCA plot. The confidence level indicates the likelihood of samples belonging to a particular MPN classification.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/4/14/10.1182_bloodadvances.2020002230/1/advancesadv2020002230f6.png?Expires=1735571911&Signature=BzgUwmiDDTcnGxBJPlNEi1BAg3oxg2mKHm0i-7YN1LoKJDZZh0caSbEKoRKVNGeI9XxNGNQ59I7pNtSI8uMdFejz4h3qtjx~P~~O-q7HfjhBdbWG7Ory4gZVqg5GptqFRiXx3EnNWf6fFLTjjz5HNfLz0K4cCAbyvApp5QbxBbf6brv5bijbHkKbdpji9HczMS8SL~Du-XP0vUh7FVB9Ll-LDh74hggGhuuBrHJXIYNDe~UJk~womF5eaGXiPoeIydm0m6MI1XwxrlKw2ConcGSNG2shkfj-X5Mjy6qNqfAVoInaV3LtJNzZJzl3hZ0KAYUgM~5JV1qqaYzCD1I58A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Examples of disease cohort indexing. Multivariable representations of individual patient samples in the context of the analyzed disease cohorts. (A) Two patients with stable disease (ET [patient 1] and refractory PV [patient 2]) in whom sequential samples were available showed close clustering of the analyzed samples on the PCA plot. (B) Two patients with transformed ET (patient 3) and PV (patient 4) showed a marked shift in the multivariable representations of megakaryocytes between the chronic MPN samples and the transformed samples (post-ET myelofibrosis and post-PV myelofibrosis, respectively) on the PCA plot. The confidence level indicates the likelihood of samples belonging to a particular MPN classification.