![Examples of disease cohort indexing. Multivariable representations of individual patient samples in the context of the analyzed disease cohorts. (A) Two patients with stable disease (ET [patient 1] and refractory PV [patient 2]) in whom sequential samples were available showed close clustering of the analyzed samples on the PCA plot. (B) Two patients with transformed ET (patient 3) and PV (patient 4) showed a marked shift in the multivariable representations of megakaryocytes between the chronic MPN samples and the transformed samples (post-ET myelofibrosis and post-PV myelofibrosis, respectively) on the PCA plot. The confidence level indicates the likelihood of samples belonging to a particular MPN classification.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/4/14/10.1182_bloodadvances.2020002230/1/advancesadv2020002230f6.png?Expires=1764922676&Signature=Og1YdzY3O5d~4Dcqx9snMFa4oxFp3s9MhVdL31P5NlYI~hveL0N1WHg5w5qVNYntZqQtovrZa1WD-TQXU7qHgMFZEiOg3vbL4dSUrjzm3G7KRA95VuUHmPo7Wx-hOWwbQyasANsD8oljWE9KyQHsSxPu-hQD1WVfg~uELcMadffH2vvfjqkjAED0~yZEIyD48EFz-DwOh2hS-~HLRuPamYEXyYPbtLGsM0UX~zcE1voJkbUwk~LpHjes8E9KE5soJykDACwxE7t1mTDA7D5nzPQ4Jw7x4ANtREWDI5Dz1z5XAolXkXU-0XCyV5t6dV9EZzg-OVnDkjjlmIvF9mQ16w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Figure 6.
Examples of disease cohort indexing. Multivariable representations of individual patient samples in the context of the analyzed disease cohorts. (A) Two patients with stable disease (ET [patient 1] and refractory PV [patient 2]) in whom sequential samples were available showed close clustering of the analyzed samples on the PCA plot. (B) Two patients with transformed ET (patient 3) and PV (patient 4) showed a marked shift in the multivariable representations of megakaryocytes between the chronic MPN samples and the transformed samples (post-ET myelofibrosis and post-PV myelofibrosis, respectively) on the PCA plot. The confidence level indicates the likelihood of samples belonging to a particular MPN classification.