Comparison of DNA methylation patterns of WM patients with normal cells reveals a range of overall differentiation states. (A) PCA of WM patients and normal MBC subsets and PCs using the 1000 most-variable CpGs among normal cells. (bottom) Comparison of the degree of differentiation between WM subtypes as assessed by PC1. (B) Comparison of differentiation with intratumor heterogeneity of DNA methylation patterns. Samples showing an intermediate degree of maturity displayed highest heterogeneity of methylation patterns, suggesting these samples are a mixture of cells with MBC-like and PC-like states.