Establishment of pan-tissue SoNar transgenic mice. (A) In vivo fluorescence imaging of neonatal SoNar transgenic mouse and WT mouse excited at 420 and 480 nm. Scale bar, 10 mm. (B) Comparison of the neonatal SoNar transgenic mouse and WT mouse under UV illumination (395 nm). (C) Representative electrophoresis images for the genotype of SoNar transgenic mice. + indicates transgenic mice; − indicates WT littermate transgenic mice; N indicates C57BL/6 WT mice. (D) mRNA levels of SoNar in different tissues/organs from the transgenic mice determined by RT-PCR. (E) SoNar fluorescence was examined in different tissues/organs of either WT or SoNar transgenic mice by confocal microscopy. Scale bar, 10 μm. See also supplemental Figure 1.