Case distribution and prevalence of gene mutations detected by RNA-seq in GCB and ABC subtypes of DLBCL. (A) Heatmap for distribution of gene mutations in GCB/ABC subtypes of DLBCL. Only genes mutated in ≥6 patients are shown. Each column is for each patient, and each row is for each gene. Frequency (prevalence) of mutations in overall DLBCL is on the right. Genes with significantly differential prevalence in GCB and ABC subtypes (determined by Affymetrix and/or IHC) are marked by asterisks. (B) Differential prevalence of mutations in DLBCL COO subtypes classified by gene expression profiling. Only the most significant genes are shown. UC, unclassified.