Collapsing test results from exome sequencing. We tested the coding sequence of 17 862 genes for greater than expected number of rare damaging variants in 373 cases vs 5784 controls. Gene names are indicated for top 4 signals. (A) Manhattan plot of −log₁₀(p) values for each gene by Fisher’s exact test. Each dot represents one of 17 862 tested genes. Number of variants and OR (cases/controls, OR) indicated for top 4 genes. (B) Quantile-Quantile plot of observed −log10(p) (y-axis) vs expected (x-axis) by Fisher’s exact test. Each dot represents one of 17 862 tested genes.