Influence of ME of HLA-A locus in HVG direction on OS, PFS, and cumulative incidence of relapse. HLA-A ME in HVG direction is associated with superior OS (A) and PFS (B), and reduced risk of relapse (C). HR and SHR represent the impact of HLA-A ME in the HVG direction on outcomes as a continuous variable, adjusted for sex, age, HCT-CI, DRI, transplant protocol, conditioning regimen intensity, donor relation, stem cell source, and ABO match.