Coagulation and fibrinolytic system components in inflammation. Summary of mechanisms by which fibrinogen, thrombin, and fibrinolytic proteins contribute to inflammatory mechanisms. Boxed A indicates FXIII A subunit; circled B indicates FXIII B subunit. APC, activated protein C; EC, endothelial cell; ePCR, endothelial cell protein C receptor; FDP, fibrin degradation product; Plg, plasminogen; Plg-R, plasminogen receptor; TF, tissue factor; tPA, tissue-type plasminogen activator; uPA, urokinase-type plasminogen activator.