(A) Onset of immunothrombosis in mice infected with STm shows up early in spleen (24 hours) and quickly subsides, whereas in liver, it emerges at a much later time point (day 7). (B) These thrombi are rich in platelet aggregates (CD41), monocytes (Ly6G⁺ and F4/80⁺), and neutrophils (myeloperoxidase [MPO] and citrullinated histone H3 [H3Cit]) and resemble the typical immunothrombosis event. Surprisingly, these thrombi contain very few bacteria, even in the presence of high bacterial burden in spleen and liver, thus raising questions on the notion that immunothrombosis is primarily a protective response against systemic bacterial infection. On the contrary, (C) in vitro, significantly high number of bacteria were captured upon platelet aggregation induced by STm.