Activity of AZD5991 and AZD5991+CHOP in vivo. (A) BH3 profile of WCTL-91953. (B) Tumor volume of mice treated with vehicle or AZD5991 once weekly (d1), n = 6 per arm. (C) Representative example of a subcutaneous tumor of WCTL-91953 before and after the third dose of AZD5991. (D) Survival curve of mice engrafted with WCTL-91953 and treated with either vehicle or AZD5991. (E) BH3 profile of the T-PLL PDX DFTL-28776. (F) Survival of mice engrafted with DFTL-28776 and treated with either vehicle or AZD5991 once weekly (d1), n = 6 per arm. DMSO, dimethyl sulfoxide.