LCMV-induced hyperinflammation decreases the apoptotic potential of CD8 T cells in Prf1^−/−mice and this apoptotic potential is restored upon treatment with RUX. (A-C) Percent priming values generated from BH3 profiling of murine CD8 T cells harvested on day 9 postinfection from naïve or vehicle- or drug-treated LCMV-infected mice prior to BH3 profiling with 10 µM ABT-199 to measure BCL-2 activity (A), 10 µM WEHI-539 to measure BCL-xL activity (B), or 10 µM S63845 to measure MCL-1 activity (C). Statistical significance was assessed using 1-way ANOVA with Tukey’s method for multiple comparisons adjustment. ****P < .0001; ***P < .001; **P < .01; *P < .05.