Genetic alterations of a human AEL cohort. Heatmap representing 3 molecular AEL subgroups: TP53-mutated (group 1), epigenetic modifier-mutated (group 2), and others (with no recurrent mutation; group 3), according to WHO 2008 and 2016 diagnosis classifications, cytogenetic risk group (IPSS-R), ELN 2017 risk stratification, methods of sequencing, number of predicted driver mutations, and type of predicted driver mutations.