Figure 7.
Hepatic Trf, iron, MDA, and SLC39A14 levels in liver biopsy samples obtained from patients with liver cirrhosis and in Trf-LKO mice. Liver biopsy samples were obtained from 20 patients with liver cirrhosis and 20 control subjects who underwent resection for hepatocellular carcinoma. (A,B) Representative images of liver sections stained with Masson’s trichrome, Trf IHC, Perls Prussian blue, MDA IHC, and SLC39A14 IHC. (C) Quantitative analyses of Trf, MDA, and SLC39A14 staining of liver sections obtained from control and cirrhotic biopsy samples. (D) Representative images of murine liver sections stained with Slc39a14 obtained from 12-week-old SID-fed and HID-fed control mice and Trf-LKO mice. The scale bars represent 100 μm. (E) Quantitative analyses of hepatic Slc39a14 staining from 12-week-old SID-fed and HID-fed control mice and Trf-LKO mice. *P < .05, **P < .01, Student t test.

Hepatic Trf, iron, MDA, and SLC39A14 levels in liver biopsy samples obtained from patients with liver cirrhosis and in Trf-LKO mice. Liver biopsy samples were obtained from 20 patients with liver cirrhosis and 20 control subjects who underwent resection for hepatocellular carcinoma. (A,B) Representative images of liver sections stained with Masson’s trichrome, Trf IHC, Perls Prussian blue, MDA IHC, and SLC39A14 IHC. (C) Quantitative analyses of Trf, MDA, and SLC39A14 staining of liver sections obtained from control and cirrhotic biopsy samples. (D) Representative images of murine liver sections stained with Slc39a14 obtained from 12-week-old SID-fed and HID-fed control mice and Trf-LKO mice. The scale bars represent 100 μm. (E) Quantitative analyses of hepatic Slc39a14 staining from 12-week-old SID-fed and HID-fed control mice and Trf-LKO mice. *P < .05, **P < .01, Student t test.

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