Pretreatment with 3G3 antibody prevented the increase in the levels of many proinflammatory cytokines, except for TNF, following a lethal dose of heat-inactivated S aureus injection in baboons. TNF-α (A), IL-6 (B), IL-8 (C), monocyte chemoattractant protein 1 (MCP1) (D), granulocyte-macrophage colony-stimulating factor (E), and IL-1β (F). Data are presented as mean ± SEM. Same time point data are compared between LD challenge (LDSA) and challenge plus 3G3 treatment (LDSA + 3G3) groups using 2-tailed Student t test: *P < .05, **P < .01, ***P < .001.