Improvement of endothelial thrombin generation in DOAC patient plasma by ^superFVa. Thrombin generation was performed in plasma from patients on chronic anticoagulation with DOACs in the presence of EA.hy926 endothelial cells (○) and in the absence of cells (□). Thrombin generation in the absence of cells was initiated by 0.4 pM tissue factor and 10 μM phospholipid vesicles (PC/PS/PE 40/20/40). Shown are the endogenous thrombin potential (ETP) (A,C,E) and the lag time (B,D,F) of thrombin generation in the presence or absence of antibodies (50 μg/mL) against (A)PC (αPC; C1) or ^superFVa (20 nM) of patients on chronic anticoagulation with apixaban (A-B), rivaroxaban (C-D) , and dabigatran (E-F).