Clinical, laboratory, and pathologic features of patients with GATA2 deficiency. (A) Clinical findings in patients II-1 and II-2. (B) Immunophenotyping of the father (I-1), and brothers (II-1 and II-2) demonstrate normal peripheral blood counts in I-1 and monocytopenia and B-cell depletion in II-1 and II-2. (C) Bone marrow biopsy showing CD34⁺ clusters by immunohistochemistry in II-1 (i) and trilineage hypoplasia in II-2 (ii) and lung biopsy demonstrating chronic lymphoplasmacytic infiltrate (iii) and alveolar proteinosis (iv) in II-1. Hematoxylin and eosin stain. Ly, lymphocytes.