Decreased vs increased oxidative burst response in neutrophils isolated from Hamp1Δ^livermice or from the EIO model, respectively. Kinetics of the oxidative burst response to fMLF, OZ, or PMA of neutrophils isolated from mice fed an iron-rich diet for 6 months (EIO) vs control mice (A) (n = 3 per group) or Hamp1Δ^liver vs Hamp1^lox/lox mice (B) (n ≥ 3 per group). Data are representative of 3 independent experiments. Statistical analysis was performed using a 2-way analysis of variance (ANOVA) followed by a Sidak test. **P < .01; ***P < .001; ****P < .0001.