In vivo antitumor activity of NEO2734 in a DLBCL xenograft model. (A) Treatment of TMD8 xenograft (ABC-DLBCL) with NEO2734, birabresib, or vehicle. Lines show median values per time point with the corresponding interquartile range. (B) The boxplot represents the tumor volumes at the best vehicle per treatment day (day 7). (C) Body weight at the first and last day of treatment. Seven mice were treated in each group. The Mann-Whitney U test was used to compare groups. *P < .05, ***P < .001.