Figure 1.
Rationale for PET imaging of VLA-4 as a biomarker of hyper-adhesion. The PET tracer 64Cu-CB-TE1A1P-PEG4-LLP2A binds specifically to the active conformation of VLA-4. VLA-4 is expressed on leukocytes and reticulocytes and contributes to vaso-occlusion.12-14,41,48

Rationale for PET imaging of VLA-4 as a biomarker of hyper-adhesion. The PET tracer 64Cu-CB-TE1A1P-PEG4-LLP2A binds specifically to the active conformation of VLA-4. VLA-4 is expressed on leukocytes and reticulocytes and contributes to vaso-occlusion.12-14,41,48 

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