Pathways overrepresented in LSCs. GSEA of LSC vs blast and LSC vs HSPC comparisons using KEGG and HALLMARK gene sets. (A) Gene sets significant in both comparisons. (B) Gene sets significant in LSC vs blast. (C) Gene sets significant in LSC vs HSPC comparisons. Pathways in bold are further analyzed in Figure 5. NES, normalized enrichment score.