Scaled density plots for VAF of CHIP-associated mutations. Targeted sequencing data were obtained from Abelson et al,²²  whole-exome sequencing (WES) data were obtained from Jaiswal et al,¹²  and whole-genome sequencing (WGS) data were obtained from Bick et al.⁴⁶  The dashed red line is drawn at variant allele fraction (VAF) 0.02, the cutoff for CHIP. The depth of coverage is the primary factor that determines the shape of the distribution for VAF.