Figure 2.
Survival analysis and kidney function in κF-DH mice. (A) Kaplan-Meier overall survival analysis of κF-DH mice (n = 12) compared with DH mice (n = 10). Note the short 8.5-month median survival for κF-DH mice compared with DH mice (all alive at 14 months). Urine albumin (B) and serum creatinine levels (C) in 2- to 8-month-old κF-DH, DH, and WT mice and in κF-DH mice at humane end point (ɵ). Urine albumin in κF-DH mice started to increase at 8 months, whereas a strong increase of serum creatinine appeared only in unhealthy mice. Survival data were analyzed using log-rank (Mantel-Cox) test, and comparisons between 2 groups were calculated using the nonparametric Mann-Whitney test. Means ± standard error of the mean, and only significant P values are indicated. *P < .05, **P < .01, ***P < .001.

Survival analysis and kidney function in κF-DH mice. (A) Kaplan-Meier overall survival analysis of κF-DH mice (n = 12) compared with DH mice (n = 10). Note the short 8.5-month median survival for κF-DH mice compared with DH mice (all alive at 14 months). Urine albumin (B) and serum creatinine levels (C) in 2- to 8-month-old κF-DH, DH, and WT mice and in κF-DH mice at humane end point (ɵ). Urine albumin in κF-DH mice started to increase at 8 months, whereas a strong increase of serum creatinine appeared only in unhealthy mice. Survival data were analyzed using log-rank (Mantel-Cox) test, and comparisons between 2 groups were calculated using the nonparametric Mann-Whitney test. Means ± standard error of the mean, and only significant P values are indicated. *P < .05, **P < .01, ***P < .001.

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