The whole-genome–wide landscape of MEITL. (A) Oncoplot of recurrent somatic short-variant mutations detected in 4 MEITL tumors. Accompanying compounds that can target the corresponding gene mutations are labeled to the left of the oncoplot. (B) Recurrent somatic copy number alteration across the 4 MEITL using WGS data: copy-gain (left) and copy-loss (right) events. The vertical green line denotes the q = 0.25 (adjusted P value) cutoff for significant copy number events. (C) 17q arm-wide shows that large-scale, copy-neutral, loss-of-heterozygosity alterations were present and affected the STAT5B loci in all our MEITLs. (D) The 100% stacked bar plots comparing the proportions of known COSMIC (Catalogue of Somatic Mutations in Cancer) mutational signatures within each MEITL tumor. The denoted mutational signature numbers are as described at https://cancer.sanger.ac.uk/cosmic/signatures. (E) Circos (http://mkweb.bcgsc.ca/circos) plots depicting the structural rearrangements as links for each WGS sample. Links are colored differently for each type of structural rearrangement: red for duplications, blue for deletions, green for inversions, and black for interchromosomal translocations.