Molecular signatures in MDS/MPN. (A) Associations among MDS/MPN subtypes and specific gene combinations. Significant associations (adjusted P-value q < 0.05) are colored by odds ratio, where green depicts positive associations and red depicts negative associations. Gene combinations were used to classify cases of MDS/MPN-U according to molecular profile: CMML-, aCML-, and MDS/MPN-RS-T–like. (B) The proportion of MDS/MPN-U cases, classified according to the molecular profile. (C) Kaplan Meier curves showing the overall survival of MDS/MPN-U molecular subtypes.